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KMID : 0359920090280020127
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Korean Journal of Nephrology
2009 Volume.28 No. 2 p.127 ~ p.134
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A Long-term Study On Changes of Serum Middle Molecules Concentration according to the Frequency of On-line Hemodiafiltration :A Comparison between 1/week and 3/week On-line Hemodiafiltration
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Lee Kyung-Eun
Oh Dong-Jin
Yu Suk-Hee
Ahn Ji-Hyun
Kim Tae-Young
Kim Sun-Min
Kim Su-Hyun
Kang Eung-Taek
Nam Woo-Jin
Shin Jung-Ho
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Abstract
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PURPOSE: The purpose of this study was to assess the effect of long-term and differing frequency of on-line hemodiafiltration (OL-HDF) on changes in degree of hemoglobin, albumin level, serum small and middle molecules concentration in stable patients with undergoing high-flux hemodialysis (HF-HD).
METHODS: Twenty five patients with more than 3 months of HF-HD were divided into two groups and followed for more than 36 months. Group 1 was treated once with OL-HDF and twice with HF-HD per week. Group 2 was treated three times with OL-HDF per week. Analysis was performed to compare hemoglobin, biochemical parameters, serum beta-microglobulin, leptin, alpha-microglobulin levels in both groups.
RESULTS: There were significant improvements in hemoglobin and albumin level in group 2 compared to group 1. After receiving OL-HDF for a mean of 24 months, patients on both groups had the significantly reduced predialysis level of beta-microglobulin compared to baseline level. However, there is no significant difference in beta-microglobulin level between both groups. The predialysis level of leptin and alpha-microglobulin with relatively large molecular weight was not significantly reduced during observational period and was not significantly different between both groups.
CONCLUSION: There were improvements in hemoglobin and albumin level according to the frequency of OL-HDF. The predialysis level of beta-microglobulin was significantly reduced after receiving even once with OL-HDF per week for long-term. Therefore, our study can suggest that there is no correlation between the frequency of OL-HDF and the predialysis level of beta-microglobulin.
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KEYWORD
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Hemodiafiltration, Hemodialysis, Beta 2-microglobulin
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